PROX1

PROX1 is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus.

prospero homeobox 1

Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.

Acinar cell differentiationIEA:Ensembl
Aorta smooth muscle tissue morphogenesisISS:BHF-UCL
Atrial cardiac muscle tissue morphogenesisISS:BHF-UCL
Blood vessel endothelial cell differentiationIEA:Ensembl
Brain developmentManual Assertion Based On ExperimentIEP:BHF-UCL
Branching involved in pancreas morphogenesisIEA:Ensembl
Cerebellar granule cell differentiationISS:BHF-UCL
Circadian rhythmIEA:Ensembl
Dentate gyrus developmentISS:BHF-UCL
Dorsal spinal cord developmentBy SimilarityISS:BHF-UCL
Embryonic retina morphogenesis in camera-type eyeManual Assertion Based On ExperimentIEP:BHF-UCL
Endocardium formationISS:BHF-UCL
Epithelial cell migrationIEA:Ensembl
Hepatocyte cell migrationIEA:Ensembl
Hepatocyte differentiationManual Assertion Based On ExperimentIEP:BHF-UCL
Hepatocyte proliferationIEA:Ensembl
Kidney developmentManual Assertion Based On ExperimentIEP:BHF-UCL
Lens development in camera-type eyeManual Assertion Based On ExperimentIEP:BHF-UCL
Lens fiber cell morphogenesisManual Assertion Based On ExperimentIEP:BHF-UCL
Lens placode formation involved in camera-type eye formationBy SimilarityISS:BHF-UCL
Liver developmentManual Assertion Based On ExperimentIEP:BHF-UCL
Lung developmentManual Assertion Based On ExperimentIEP:BHF-UCL
LymphangiogenesisManual Assertion Based On ExperimentIDA:BHF-UCL
Lymphatic endothelial cell differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Lymphatic endothelial cell fate commitmentManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of bile acid biosynthetic processManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of DNA-binding transcription factor activityManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of neuroblast proliferationIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of viral genome replicationManual Assertion Based On ExperimentIDA:BHF-UCL
Neural tube developmentBy SimilarityISS:BHF-UCL
Neuroblast proliferationIEA:Ensembl
Neuron fate determinationIEA:Ensembl
Neuronal stem cell population maintenanceISS:BHF-UCL
Olfactory placode formationBy SimilarityISS:BHF-UCL
Otic placode formationBy SimilarityISS:BHF-UCL
Pancreas developmentManual Assertion Based On ExperimentIEP:BHF-UCL
Positive regulation of cell cycleISS:BHF-UCL
Positive regulation of cell cycle checkpointIEA:Ensembl
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of cyclin-dependent protein serine/threonine kinase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of endothelial cell migrationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of endothelial cell proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of forebrain neuron differentiationISS:BHF-UCL
Positive regulation of heart growthISS:BHF-UCL
Positive regulation of neural precursor cell proliferationISS:BHF-UCL
Positive regulation of sarcomere organizationISS:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of circadian rhythmManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of gene expressionManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to nutrient levelsIEA:Ensembl
Retina morphogenesis in camera-type eyeBy SimilarityISS:BHF-UCL
Skeletal muscle thin filament assemblyISS:BHF-UCL
Transcription by RNA polymerase IIIEA:Ensembl
Venous blood vessel morphogenesisISS:BHF-UCL
Ventricular cardiac muscle tissue morphogenesisISS:BHF-UCL
Ventricular cardiac myofibril assemblyISS:BHF-UCL
Ventricular septum morphogenesisISS:BHF-UCL

Nucleus
RORG promotes its nuclear localization.