Mouse Anti-PROX1 Monoclonal Antibody (1A6) (CBMAB-0013-LY)

prospero homeobox 1

The gene encodes the protein which is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA.

Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.

Acinar cell differentiationIEA:Ensembl
Aorta smooth muscle tissue morphogenesisISS:BHF-UCL
Atrial cardiac muscle tissue morphogenesisISS:BHF-UCL
Blood vessel endothelial cell differentiationIEA:Ensembl
Brain developmentManual Assertion Based On ExperimentIEP:BHF-UCL
Branching involved in pancreas morphogenesisIEA:Ensembl
Cerebellar granule cell differentiationISS:BHF-UCL
Circadian rhythmIEA:Ensembl
Dentate gyrus developmentISS:BHF-UCL
Dorsal spinal cord developmentBy SimilarityISS:BHF-UCL
Embryonic retina morphogenesis in camera-type eyeManual Assertion Based On ExperimentIEP:BHF-UCL
Endocardium formationISS:BHF-UCL
Epithelial cell migrationIEA:Ensembl
Hepatocyte cell migrationIEA:Ensembl
Hepatocyte differentiationManual Assertion Based On ExperimentIEP:BHF-UCL
Hepatocyte proliferationIEA:Ensembl
Kidney developmentManual Assertion Based On ExperimentIEP:BHF-UCL
Lens development in camera-type eyeManual Assertion Based On ExperimentIEP:BHF-UCL
Lens fiber cell morphogenesisManual Assertion Based On ExperimentIEP:BHF-UCL
Lens placode formation involved in camera-type eye formationBy SimilarityISS:BHF-UCL
Liver developmentManual Assertion Based On ExperimentIEP:BHF-UCL
Lung developmentManual Assertion Based On ExperimentIEP:BHF-UCL
LymphangiogenesisManual Assertion Based On ExperimentIDA:BHF-UCL
Lymphatic endothelial cell differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Lymphatic endothelial cell fate commitmentManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of bile acid biosynthetic processManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of DNA-binding transcription factor activityManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of neuroblast proliferationIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of viral genome replicationManual Assertion Based On ExperimentIDA:BHF-UCL
Neural tube developmentBy SimilarityISS:BHF-UCL
Neuroblast proliferationIEA:Ensembl
Neuron fate determinationIEA:Ensembl
Neuronal stem cell population maintenanceISS:BHF-UCL
Olfactory placode formationBy SimilarityISS:BHF-UCL
Otic placode formationBy SimilarityISS:BHF-UCL
Pancreas developmentManual Assertion Based On ExperimentIEP:BHF-UCL
Positive regulation of cell cycleISS:BHF-UCL
Positive regulation of cell cycle checkpointIEA:Ensembl
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of cyclin-dependent protein serine/threonine kinase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of endothelial cell migrationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of endothelial cell proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of forebrain neuron differentiationISS:BHF-UCL
Positive regulation of heart growthISS:BHF-UCL
Positive regulation of neural precursor cell proliferationISS:BHF-UCL
Positive regulation of sarcomere organizationISS:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of circadian rhythmManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of gene expressionManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to nutrient levelsIEA:Ensembl
Retina morphogenesis in camera-type eyeBy SimilarityISS:BHF-UCL
Skeletal muscle thin filament assemblyISS:BHF-UCL
Transcription by RNA polymerase IIIEA:Ensembl
Venous blood vessel morphogenesisISS:BHF-UCL
Ventricular cardiac muscle tissue morphogenesisISS:BHF-UCL
Ventricular cardiac myofibril assemblyISS:BHF-UCL
Ventricular septum morphogenesisISS:BHF-UCL

Nucleus
RORG promotes its nuclear localization.