PROZ

PROZ is a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency.
Full Name
protein Z, vitamin K dependent plasma glycoprotein
Function
Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids.
Biological Process
Blood coagulationManual Assertion Based On ExperimentIBA:GO_Central
ProteolysisIEA:InterPro
Cellular Location
Secreted
PTM
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
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Anti-PROZ antibodies

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Mouse Anti-PROZ Recombinant Antibody (4D5) (CBMAB-P3005-YC)

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Target: PROZ
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4D5
Application*: IH
Datasheet SDS

Mouse Anti-PROZ Recombinant Antibody (2B4) (CBMAB-P3004-YC)

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Target: PROZ
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2B4
Application*: E, WB, P, IF, IC, F
Datasheet SDS

Mouse Anti-PROZ Recombinant Antibody (CBT1069) (V2LY-0625-LY3060)

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Target: PROZ
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT1069
Application*: WB, E
Datasheet SDS

Mouse Anti-PROZ Recombinant Antibody (CBT4552) (V2LY-0625-LY2306)

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Target: PROZ
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4552
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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