PSMD11

PSMD11 (Proteasome 26S Subunit, Non-ATPase 11) is a protein coding gene. Among its related pathways are Cell Cycle, Mitotic and RET signaling. An important paralog of the gene is COPS2.

Full Name

Proteasome 26S Subunit, Non-ATPase 11

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity.

Biological Process

Proteasome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Proteasome-mediated ubiquitin-dependent protein catabolic process1 PublicationIC:ComplexPortal
Stem cell differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus
Cytoplasm, cytosol

PTM

Phosphorylated by AMPK.