Mouse Anti-PSMD11 Recombinant Antibody (1F4) (CBMAB-P3217-YC)

Name: Mouse Anti-PSMD11 Recombinant Antibody (1F4)
SKU: CBMAB-P3217-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

1F4

Application

WB, ELISA

Immunogen

Recombinant human PSMD11 (1-422aa) purified from E. coli (NP_002806)

Specificity

Human, Mouse, C. elegans

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Proteasome 26S Subunit, Non-ATPase 11

Introduction

PSMD11 (Proteasome 26S Subunit, Non-ATPase 11) is a protein coding gene. Among its related pathways are Cell Cycle, Mitotic and RET signaling. An important paralog of the gene is COPS2.

Entrez Gene ID

Human	5717
Mouse	69077

UniProt ID

Human	O00231
Mouse	Q8BG32

Alternative Names

Rpn6; S9; p44.5

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity.

Biological Process

Proteasome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Proteasome-mediated ubiquitin-dependent protein catabolic process1 PublicationIC:ComplexPortal
Stem cell differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus
Cytoplasm, cytosol

PTM

Phosphorylated by AMPK.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Rabbit Anti-PSMD11 Recombinant Antibody (D1T1R) (CAT#: CBMAB-P3218-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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