PSMD14

PSMD14 is a component of the 26S proteasome, a multiprotein complex that degrades proteins targeted for destruction by the ubiquitin pathway (Spataro et al., 1997 [PubMed 9374539]).[supplied by OMIM

Full Name

proteasome (prosome, macropain) 26S subunit, non-ATPase, 14

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.

Biological Process

Double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIMP:UniProtKB
Double-strand break repair via nonhomologous end joiningManual Assertion Based On ExperimentIMP:UniProtKB
Proteasome-mediated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Protein deubiquitinationManual Assertion Based On ExperimentIBA:GO_Central
Protein K63-linked deubiquitinationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of proteasomal protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Response to ethanolIEA:Ensembl
Ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentTAS:UniProtKB

Cellular Location

cytosol
cytosolic proteasome complex
extracellular region
ficolin-1-rich granule lumen
nucleoplasm
nucleus
proteasome accessory complex
proteasome complex
proteasome regulatory particle, lid subcomplex
secretory granule lumen