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Rabbit Anti-PSMD14 Recombinant Antibody (D18C7) (CBMAB-P3221-YC)

Provided herein is a Rabbit monoclonal antibody against Human Proteasome 26S Subunit, Non-ATPase 14. The antibody can be used for immunoassay techniques, such as WB, IP.
See all PSMD14 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey, Frog, Dog
Clone
D18C7
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human, Mouse, Rat, Monkey, Frog, Dog
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
Introduction
PSMD14 (Proteasome 26S Subunit, Non-ATPase 14) is a protein coding gene. Among its related pathways are Cell Cycle, Mitotic and RET signaling. Gene Ontology annotations related to this gene include metallopeptidase activity and proteasome binding.
Entrez Gene ID
Human10213
Mouse59029
Rat311078
Frog595024
Monkey701063
Dog478765
UniProt ID
HumanO00487
MouseO35593
RatQ4V8E2
FrogF6ZSY4
MonkeyF7HMX1
DogF1PGY4
Alternative Names
PAD1; POH1; RPN11
Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.
Biological Process
Double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIMP:UniProtKB
Double-strand break repair via nonhomologous end joiningManual Assertion Based On ExperimentIMP:UniProtKB
Proteasome-mediated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Protein deubiquitinationManual Assertion Based On ExperimentIBA:GO_Central
Protein K63-linked deubiquitinationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of proteasomal protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Response to ethanolIEA:Ensembl
Ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
cytosol
cytosolic proteasome complex
extracellular region
ficolin-1-rich granule lumen
nucleoplasm
nucleus
proteasome accessory complex
proteasome complex
proteasome regulatory particle, lid subcomplex
secretory granule lumen
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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