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PTGER2

PTGER2 is a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma

Full Name

Prostaglandin E Receptor 2

Function

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathwayISS:BHF-UCL
Cellular response to prostaglandin E stimulusISS:BHF-UCL
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cytosolic calcium ion concentrationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell population proliferationIEA:Ensembl
Response to lipopolysaccharideIEA:Ensembl
Response to nematodeIEA:Ensembl
Response to progesteroneIEA:Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 1-23
Helical: 24-47
Cytoplasmic: 48-65
Helical: 66-91
Extracellular: 92-111
Helical: 112-132
Cytoplasmic: 133-151
Helical: 152-176
Extracellular: 177-198
Helical: 199-223
Cytoplasmic: 224-262
Helical: 263-286
Extracellular: 287-299
Helical: 300-323
Cytoplasmic: 324-358

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Anti-PTGER2 antibodies

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Mouse Anti-PTGER2 Recombinant Antibody (CBYC-P748) (CBMAB-P3322-YC)

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Target: PTGER2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYC-P748

Application*: WB, IH

Mouse Anti-PTGER2 Recombinant Antibody (3F12) (CBMAB-P3321-YC)

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Target: PTGER2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: 3F12

Application*: WB

Mouse Anti-PTGER2 Recombinant Antibody (CBFYE-1613) (CBMAB-E2272-FY)

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Target: PTGER2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat

Clone: CBFYE-1613

Application*: WB

Rabbit Anti-PTGER2 Recombinant Antibody (
8D8) (V2LY-0725-LY1281)

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Target: PTGER2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 8D8

Application*: E, IH

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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