PTGIR

The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq]

prostaglandin I2 (prostacyclin) receptor (IP)

Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.

Adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of platelet-derived growth factor receptor signaling pathwayBy SimilarityISS:BHF-UCL
Negative regulation of smooth muscle cell proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of cytosolic calcium ion concentrationManual Assertion Based On ExperimentIBA:GO_Central
Response to lipopolysaccharideIEA:Ensembl

Cell membrane

Extracellular: 1-16
Helical: 17-38
Cytoplasmic: 39-51
Helical: 52-76
Extracellular: 77-94
Helical: 95-115
Cytoplasmic: 116-134
Helical: 135-158
Extracellular: 159-181
Helical: 182-208
Cytoplasmic: 209-235
Helical: 236-260
Extracellular: 261-274
Helical: 275-295
Cytoplasmic: 296-386

Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C.