PTGIR

The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq]

Full Name

prostaglandin I2 (prostacyclin) receptor (IP)

Function

Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of platelet-derived growth factor receptor signaling pathwayBy SimilarityISS:BHF-UCL
Negative regulation of smooth muscle cell proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of cytosolic calcium ion concentrationManual Assertion Based On ExperimentIBA:GO_Central
Response to lipopolysaccharideIEA:Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 1-16
Helical: 17-38
Cytoplasmic: 39-51
Helical: 52-76
Extracellular: 77-94
Helical: 95-115
Cytoplasmic: 116-134
Helical: 135-158
Extracellular: 159-181
Helical: 182-208
Cytoplasmic: 209-235
Helical: 236-260
Extracellular: 261-274
Helical: 275-295
Cytoplasmic: 296-386

PTM

Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C.