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Mouse Anti-PTGIR Recombinant Antibody (4B10) (CBMAB-P3333-YC)

Provided herein is a Mouse monoclonal antibody against Human Prostaglandin I2 (prostacyclin) receptor (IP). The antibody can be used for immunoassay techniques, such as ELISA, IHC-P, WB.
See all PTGIR antibodies
Published Data
Fig.2 Qualitative and quantitative analyses of EZH2 protein expression are shown in Iia.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
4B10
Antibody Isotype
IgG1, κ
Application
ELISA, IHC-P, WB

Basic Information

Immunogen
PTGIR (NP_000951, 296-386 aa) partial recombinant protein with GST tag. Immunogen sequence: RKAVFQRLKL WVCCLCLGPA HGDSQTPLSQ LASGRRDPRA PSAPVGKEGS CVPLSAWGEG QVEPLPPTQQ SSGSAVGTSS KAEASVACSL C
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 296-386

Target

Full Name
prostaglandin I2 (prostacyclin) receptor (IP)
Introduction
PTGIR is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor.
Entrez Gene ID
5739
UniProt ID
P43119
Alternative Names
PRIPR; IP
Function
Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of platelet-derived growth factor receptor signaling pathwayBy SimilarityISS:BHF-UCL
Negative regulation of smooth muscle cell proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of cytosolic calcium ion concentrationManual Assertion Based On ExperimentIBA:GO_Central
Response to lipopolysaccharideIEA:Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 1-16
Helical: 17-38
Cytoplasmic: 39-51
Helical: 52-76
Extracellular: 77-94
Helical: 95-115
Cytoplasmic: 116-134
Helical: 135-158
Extracellular: 159-181
Helical: 182-208
Cytoplasmic: 209-235
Helical: 236-260
Extracellular: 261-274
Helical: 275-295
Cytoplasmic: 296-386
PTM
Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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