PTP4A1

PTP4A1 is a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis.

Full Name

Protein tyrosine phosphatase type IVA, member 1

Function

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.

Biological Process

Cell cycleIEA:UniProtKB-KW
Positive regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Protein dephosphorylationIEA:InterPro

Cellular Location

Cell membrane
Early endosome
Endoplasmic reticulum
Cytoplasm
Cytoplasm, cytoskeleton, spindle
Nucleus
And mitotic spindle.

PTM

Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus.