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PTP99A

Protein tyrosine phosphatase 99A (Ptp99A) is a transmembrane receptor tyrosine phosphatase. Its single mutants have no known phenotypes, but Ptp99A synergizes with Ptp69D to increase the penetrance of the Ptp69D motor axon defects. Ptp99A mutations also suppress the 'bypass' motor axon phenotype produced by Lar mutations.

Full Name

Ptp99A

Function

May play a key role in signal transduction and growth control. May have a role in the establishment of the intersegmental and segmental nerves.

Biological Process

Axonal defasciculationManual Assertion Based On ExperimentTAS:FlyBase
Defasciculation of motor neuron axonManual Assertion Based On ExperimentIGI:FlyBase
Motor neuron axon guidanceManual Assertion Based On ExperimentIGI:FlyBase
Peptidyl-tyrosine dephosphorylationManual Assertion Based On ExperimentIDA:FlyBase
Protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Membrane

Topology

Extracellular: 29-394
Helical: 395-415
Cytoplasmic: 416-1301

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Anti-PTP99A antibodies

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Mouse Anti-PTP99A Recombinant Antibody (4C71B7) (CBMAB-0215-CN)

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Target: PTP99A

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Common fruit fly

Clone: 4C71B7

Application*: E

Mouse Anti-PTP99A Recombinant Antibody (3A6) (CBMAB-0167-CN)

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Target: PTP99A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Common fruit fly

Clone: 3A6

Application*: E

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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