PTPRR

PTPRR is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12.

Full Name

Protein tyrosine phosphatase, receptor type R

Function

Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity).

Biological Process

ERBB2 signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
In utero embryonic developmentManual Assertion Based On ExperimentIEP:UniProtKB
Negative regulation of epithelial cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Peptidyl-tyrosine dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Protein dephosphorylationManual Assertion Based On ExperimentTAS:ProtInc
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Isoform Alpha
Cell membrane
Isoform Delta
Cytoplasm, perinuclear region
Locates to the perinuclear areas within the cytoplasm.
Isoform Gamma
Cytoplasm, perinuclear region
Locates to the perinuclear areas within the cytoplasm.

Topology

Extracellular: 22-227
Helical: 228-248
Cytoplasmic: 249-657