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Mouse Anti-PTPRR Recombinant Antibody (6A6) (CBMAB-P3486-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein tyrosine phosphatase, receptor type R. The antibody can be used for immunoassay techniques, such as IHC-Fr, IP, WB.
See all PTPRR antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
6A6
Antibody Isotype
IgG2a
Application
IHC-Fr, IP, WB

Basic Information

Immunogen
Recombinant PTP-SL-GST (NCBI accession number BN000437, expression vector pGEX-2T), expressed in E. coli
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Protein tyrosine phosphatase, receptor type R
Introduction
PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer.
Entrez Gene ID
5801
UniProt ID
Q15256
Alternative Names
PCPTP1; EC-PTP; PTP-SL; PTPRQ; PTPBR7
Function
Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity).
Biological Process
ERBB2 signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
In utero embryonic developmentManual Assertion Based On ExperimentIEP:UniProtKB
Negative regulation of epithelial cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Peptidyl-tyrosine dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Protein dephosphorylationManual Assertion Based On ExperimentTAS:ProtInc
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Isoform Alpha
Cell membrane
Isoform Delta
Cytoplasm, perinuclear region
Locates to the perinuclear areas within the cytoplasm.
Isoform Gamma
Cytoplasm, perinuclear region
Locates to the perinuclear areas within the cytoplasm.
Topology
Extracellular: 22-227
Helical: 228-248
Cytoplasmic: 249-657
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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