Sign in or Register   Sign in or Register
  |  

PTPRZ1

PTPRZ1 is a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS.
Full Name
Protein tyrosine phosphatase, receptor type Z1
Function
Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity).
Biological Process
AxonogenesisIEA:Ensembl
Central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Hematopoietic progenitor cell differentiationIEA:Ensembl
Learning or memoryISS:UniProtKB
Negative regulation of neuron apoptotic processISS:UniProtKB
Oligodendrocyte differentiationISS:UniProtKB
Peptidyl-tyrosine dephosphorylationISS:UniProtKB
Positive regulation of oligodendrocyte differentiationISS:UniProtKB
Protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of myelinationISS:UniProtKB
Regulation of oligodendrocyte progenitor proliferationISS:UniProtKB
Cellular Location
Isoform 1
Cell membrane
Secreted
A secreted form is apparently generated by shedding of the extracellular domain.
Isoform 2
Secreted
Topology
Extracellular: 25-1636
Helical: 1637-1662
Cytoplasmic: 1663-2315

Anti-PTPRZ1 antibodies

Loading...
Target: PTPRZ1
Host: Mouse
Antibody Isotype: IgM
Specificity: Chicken
Clone: CBYC-P791
Application*: E, P, WB
Target: PTPRZ1
Host: Mouse
Antibody Isotype: IgM
Specificity: Rat
Clone: 122.2
Application*: WB, IF, IP
Target: PTPRZ1
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: 279244
Application*: WB
Target: PTPRZ1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: 279245
Application*: IH
Target: PTPRZ1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MM0887-36D27
Application*: E, WB
Target: PTPRZ1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 12/RPTPb
Application*: WB, IF, IH, IP
Target: PTPRZ1
Host: Mouse
Antibody Isotype: IgM
Specificity: Rat
Clone: CBYC-P790
Application*: IC, IH, IP, WB
Target: PTPRZ1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 2B49
Application*: IH, WB
Target: PTPRZ1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 3F8
Application*: E
Target: PTPRZ1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat
Clone: 3H1
Application*: E
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
Go to
Compare