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Rat Anti-PTPRZ1 Recombinant Antibody (279244) (CBMAB-1738-CN)

This product is a rat antibody that recognizes PTPRZ1 of human. The antibody 279244 can be used for immunoassay techniques such as: WB.
See all PTPRZ1 antibodies

Summary

Host Animal
Rat
Specificity
Human
Clone
279244
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
E. coli-derived recombinant human PTP beta /zeta /PTPRZ Gly302-Asn754.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS, Trehalose.
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Protein tyrosine phosphatase, receptor type Z1
Introduction
This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. The protein is required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis.
Entrez Gene ID
5803
UniProt ID
P23471
Alternative Names
PTPZ; HPTPZ; PTP18; PTPRZ; RPTPB; HPTPzeta; PTP-ZETA; RPTPbeta; phosphacan; R-PTP-zeta-2
Function
Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity).
Biological Process
AxonogenesisIEA:Ensembl
Central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Hematopoietic progenitor cell differentiationIEA:Ensembl
Learning or memoryISS:UniProtKB
Negative regulation of neuron apoptotic processISS:UniProtKB
Oligodendrocyte differentiationISS:UniProtKB
Peptidyl-tyrosine dephosphorylationISS:UniProtKB
Positive regulation of oligodendrocyte differentiationISS:UniProtKB
Protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of myelinationISS:UniProtKB
Regulation of oligodendrocyte progenitor proliferationISS:UniProtKB
Cellular Location
Isoform 1
Cell membrane
Secreted
A secreted form is apparently generated by shedding of the extracellular domain.
Isoform 2
Secreted
Topology
Extracellular: 25-1636
Helical: 1637-1662
Cytoplasmic: 1663-2315
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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