RAB17

The Rab subfamily of small GTPases plays an important role in the regulation of membrane trafficking. RAB17 is an epithelial cell-specific GTPase (Lutcke et al., 1993 [PubMed 8486736]).[supplied by OMIM, Oct 2009]

RAB17, Member RAS Oncogene Family

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity).
May also play a role in cell migration.

Biological Process cilium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endocytic recyclingISS:UniProtKB
Biological Process endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process establishment of melanosome localizationISS:UniProtKB
Biological Process filopodium assemblyISS:UniProtKB
Biological Process immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptorISS:UniProtKB
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process melanosome transportISS:UniProtKB
Biological Process regulation of dendrite developmentISS:UniProtKB
Biological Process regulation of endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of filopodium assemblyISS:UniProtKB
Biological Process regulation of synapse assemblyISS:UniProtKB
Biological Process transcytosisISS:UniProtKB

Recycling endosome membrane
Melanosome
Cell projection, dendrite
May also localize at the basolateral and apical plasma membrane. In neurons, localizes to the cell body and dendritic shaft and spine.