Mouse Anti-RAB17 Recombinant Antibody (4E7) (CBMAB-R0719-CN)

Name: Mouse Anti-RAB17 Recombinant Antibody (4E7)
SKU: CBMAB-R0719-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

4E7

Application

WB, IHC, IF

Immunogen

Full length human recombinant protein of human RAB17 (NP_071894) produced in HEK293T cell

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.3, 1% BSA, 50% Glycerol

Preservative

0.02% Sodium azide

Concentration

0.61 mg/mL

More Infomation

Target

Full Name

RAB17, Member RAS Oncogene Family

Introduction

The Rab subfamily of small GTPases plays an important role in the regulation of membrane trafficking. RAB17 is an epithelial cell-specific GTPase (Lutcke et al., 1993 [PubMed 8486736]). [supplied by OMIM, Oct 2009]

Entrez Gene ID

64284

UniProt ID

Q9H0T7

Alternative Names

RAB17, Member RAS Oncogene Family;

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity).
May also play a role in cell migration.

Biological Process

Biological Process cilium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endocytic recyclingISS:UniProtKB
Biological Process endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process establishment of melanosome localizationISS:UniProtKB
Biological Process filopodium assemblyISS:UniProtKB
Biological Process immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptorISS:UniProtKB
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process melanosome transportISS:UniProtKB
Biological Process regulation of dendrite developmentISS:UniProtKB
Biological Process regulation of endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of filopodium assemblyISS:UniProtKB
Biological Process regulation of synapse assemblyISS:UniProtKB
Biological Process transcytosisISS:UniProtKB

Cellular Location

Recycling endosome membrane
Melanosome
Cell projection, dendrite
May also localize at the basolateral and apical plasma membrane. In neurons, localizes to the cell body and dendritic shaft and spine.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

RAB17 Matched Antibody Pair (953) (CAT#: APMAB-953LY)

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RAB17 Matched Antibody Pair (953) (CAT#: APMAB-953LY)

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Rabbit Anti-RAB17 Recombinant Antibody (D2B2) (CAT#: CBMAB-R0723-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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