RAB43

RAB43 (RAB43, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB19.

Full Name

RAB43, member RAS oncogene family

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.

Biological Process

Biological Process autophagosome assemblyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to interferon-gammaIEA:Ensembl
Biological Process Golgi organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process phagosome maturationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process retrograde transport, plasma membrane to GolgiManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process toxin transportIEA:Ensembl
Biological Process virion assemblyManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasmic vesicle, phagosome
Cytoplasmic vesicle, phagosome membrane
Golgi apparatus
Golgi apparatus, trans-Golgi network membrane
Golgi apparatus, trans-Golgi network
Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211).