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Mouse Anti-RAB43 Recombinant Antibody (5G4) (CBMAB-R0881-CN)

This product is a Mouse antibody that recognizes RAB43. The antibody 5G4 can be used for immunoassay techniques such as: ELISA, IHC, WB.
See all RAB43 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5G4
Antibody Isotype
IgG2a, κ
Application
ELISA, IHC, WB

Basic Information

Immunogen
Partial recombinant protein corresponding to aa. 113-211 from human RAB43 (NP_940892) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
RAB43, member RAS oncogene family
Introduction
RAB43 (RAB43, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB19.
Entrez Gene ID
339122
UniProt ID
Q86YS6
Alternative Names
RAB43, Member RAS Oncogene Family; Ras-Related Protein Rab-41; RAB41; Ras-Related Protein Rab-43; RAB11B;
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.
Biological Process
Biological Process autophagosome assemblyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to interferon-gammaIEA:Ensembl
Biological Process Golgi organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process phagosome maturationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process retrograde transport, plasma membrane to GolgiManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process toxin transportIEA:Ensembl
Biological Process virion assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasmic vesicle, phagosome
Cytoplasmic vesicle, phagosome membrane
Golgi apparatus
Golgi apparatus, trans-Golgi network membrane
Golgi apparatus, trans-Golgi network
Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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