RAB8B

RAB proteins, like RAB8B, are low molecular mass monomeric GTPases that localize on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB proteins function in intracellular vesicle transport by aiding in the docking and/or fusion of vesicles with their target membranes (summary by Chen et al., 1997 [PubMed 9030196]). [supplied by OMIM, Nov 2010]

Full Name

RAB8B, member RAS oncogene family

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity).

Biological Process

Biological Process antigen processing and presentationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cell-substrate junction organizationISS:UniProtKB
Biological Process endocytic recyclingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process Golgi vesicle fusion to target membraneManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of cell projection organizationIEA:Ensembl
Biological Process positive regulation of corticotropin secretionIEA:Ensembl
Biological Process protein import into peroxisome membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein localization to plasma membraneManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein secretionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle docking involved in exocytosisManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane
Cytoplasmic vesicle, phagosome
Cytoplasmic vesicle, phagosome membrane
Recruited to phagosomes containing S.aureus or M.tuberculosis.

PTM

Phosphorylation of Thr-72 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.