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Mouse Anti-RAB8B Recombinant Antibody (1E4) (CBMAB-R0944-CN)

This product is a Mouse antibody that recognizes RAB8B. The antibody 1E4 can be used for immunoassay techniques such as: ELISA, WB.
See all RAB8B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1E4
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa. 101-208 from human RAB8B (NP_057614) with GST tag
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
RAB8B, member RAS oncogene family
Introduction
RAB proteins, like RAB8B, are low molecular mass monomeric GTPases that localize on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB proteins function in intracellular vesicle transport by aiding in the docking and/or fusion of vesicles with their target membranes (summary by Chen et al., 1997 [PubMed 9030196]). [supplied by OMIM, Nov 2010]
Entrez Gene ID
51762
UniProt ID
Q92930
Alternative Names
RAB8B, Member RAS Oncogene Family;
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity).
Biological Process
Biological Process antigen processing and presentationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cell-substrate junction organizationISS:UniProtKB
Biological Process endocytic recyclingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process Golgi vesicle fusion to target membraneManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of cell projection organizationIEA:Ensembl
Biological Process positive regulation of corticotropin secretionIEA:Ensembl
Biological Process protein import into peroxisome membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein localization to plasma membraneManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein secretionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle docking involved in exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Cytoplasmic vesicle, phagosome
Cytoplasmic vesicle, phagosome membrane
Recruited to phagosomes containing S.aureus or M.tuberculosis.
PTM
Phosphorylation of Thr-72 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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