RABGAP1L

RABGAP1L (RAB GTPase Activating Protein 1 Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Rab GTPase binding. An important paralog of this gene is RABGAP1.

Full Name

RAB GTPase activating protein 1-like

Function

GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (PubMed:16923123).
Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity).

Biological Process

Biological Process activation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process endocytosisIEA:UniProtKB-KW
Biological Process protein transportIEA:UniProtKB-KW
Biological Process regulation of protein localizationManual Assertion Based On ExperimentIDA:MGI

Cellular Location

Cytoplasmic vesicle
Early endosome
Golgi apparatus
Colocalizes on endosomes partially with EEA1 (PubMed:16923123).
Colocalizes and cotransports on motile vesicles with ANK2 (By similarity).

Involvement in disease

Leukemia, acute myelogenous (AML):
A subtype of acute leukemia, a cancer of the white blood cells. AML is a malignant disease of bone marrow characterized by maturational arrest of hematopoietic precursors at an early stage of development. Clonal expansion of myeloid blasts occurs in bone marrow, blood, and other tissue. Myelogenous leukemias develop from changes in cells that normally produce neutrophils, basophils, eosinophils and monocytes.