Mouse Anti-RABGAP1L Recombinant Antibody (CBCNR-083) (CBMAB-R0972-CN)

Name: Mouse Anti-RABGAP1L Recombinant Antibody (CBCNR-083)
SKU: CBMAB-R0972-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBCNR-083

Application

WB, ELISA

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

1 mg/mL

More Infomation

Target

Full Name

RAB GTPase activating protein 1-like

Introduction

RABGAP1L (RAB GTPase Activating Protein 1 Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Rab GTPase binding. An important paralog of this gene is RABGAP1.

Entrez Gene ID

9910

UniProt ID

B7ZAP0

Alternative Names

RAB GTPase Activating Protein 1 Like; HHL; Expressed In Hematopoietic Cells, Heart, Liver (HLL); Rab GTPase-Activating Protein 1-Like; TBC1 Domain Family, Member 18; KIAA0471; TBC1D18;

Function

GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (PubMed:16923123).
Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity).

Biological Process

Biological Process activation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process endocytosisIEA:UniProtKB-KW
Biological Process protein transportIEA:UniProtKB-KW
Biological Process regulation of protein localizationManual Assertion Based On ExperimentIDA:MGI

Cellular Location

Cytoplasmic vesicle
Early endosome
Golgi apparatus
Colocalizes on endosomes partially with EEA1 (PubMed:16923123).
Colocalizes and cotransports on motile vesicles with ANK2 (By similarity).

Involvement in disease

Leukemia, acute myelogenous (AML):
A subtype of acute leukemia, a cancer of the white blood cells. AML is a malignant disease of bone marrow characterized by maturational arrest of hematopoietic precursors at an early stage of development. Clonal expansion of myeloid blasts occurs in bone marrow, blood, and other tissue. Myelogenous leukemias develop from changes in cells that normally produce neutrophils, basophils, eosinophils and monocytes.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-RABGAP1L Recombinant Antibody (2D3) (CAT#: CBMAB-R0971-CN)

Isotype control

For research use only. Not intended for any clinical use.

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