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Mouse Anti-RABGAP1L Recombinant Antibody (CBCNR-083) (CBMAB-R0972-CN)

This product is a Mouse antibody that recognizes RABGAP1L. The antibody CBCNR-083 can be used for immunoassay techniques such as: WB, ELISA.
See all RABGAP1L antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNR-083
Antibody Isotype
IgG1
Application
WB, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL

Target

Full Name
RAB GTPase activating protein 1-like
Introduction
RABGAP1L (RAB GTPase Activating Protein 1 Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Rab GTPase binding. An important paralog of this gene is RABGAP1.
Entrez Gene ID
9910
UniProt ID
B7ZAP0
Alternative Names
RAB GTPase Activating Protein 1 Like; HHL; Expressed In Hematopoietic Cells, Heart, Liver (HLL); Rab GTPase-Activating Protein 1-Like; TBC1 Domain Family, Member 18; KIAA0471; TBC1D18;
Function
GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (PubMed:16923123).
Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity).
Biological Process
Biological Process activation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process endocytosisIEA:UniProtKB-KW
Biological Process protein transportIEA:UniProtKB-KW
Biological Process regulation of protein localizationManual Assertion Based On ExperimentIDA:MGI
Cellular Location
Cytoplasmic vesicle
Early endosome
Golgi apparatus
Colocalizes on endosomes partially with EEA1 (PubMed:16923123).
Colocalizes and cotransports on motile vesicles with ANK2 (By similarity).
Involvement in disease
Leukemia, acute myelogenous (AML):
A subtype of acute leukemia, a cancer of the white blood cells. AML is a malignant disease of bone marrow characterized by maturational arrest of hematopoietic precursors at an early stage of development. Clonal expansion of myeloid blasts occurs in bone marrow, blood, and other tissue. Myelogenous leukemias develop from changes in cells that normally produce neutrophils, basophils, eosinophils and monocytes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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