RAD54B

The protein encoded by this gene belongs to the DEAD-like helicase superfamily. It shares similarity with Saccharomyces cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of DNA. This protein binds to double-stranded DNA, and displays ATPase activity in the presence of DNA. This gene is highly expressed in testis and spleen, which suggests active roles in meiotic and mitotic recombination. Homozygous mutations of this gene were observed in primary lymphoma and colon cancer. [provided by RefSeq, Jul 2008]

Full Name

RAD54 Homolog B (S. Cerevisiae)

Function

Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epistasis group.

Biological Process

Biological Process determination of adult lifespanIEA:Ensembl
Biological Process double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIDA:MGI
Biological Process mitotic recombinationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process reciprocal meiotic recombinationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process response to ionizing radiationIEA:Ensembl
Biological Process response to xenobiotic stimulusIEA:Ensembl

Cellular Location

Nucleus