RASSF7

Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway.

Ras Association Domain Family Member 7

Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization.

Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process regulation of microtubule cytoskeleton organizationIEA:InterPro
Biological Process signal transductionIEA:InterPro

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Colocalizes with gamma-tubulin.

Polyubiquitinated and degraded by the proteasome upon prolonged stress stimuli.