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Mouse Anti-RASSF7 Recombinant Antibody (H-RAS-03) (CBMAB-H3785-FY)

This product is mouse antibody that recognizes RASSF7. The antibody H-RAS-03 can be used for immunoassay techniques such as: WB.
See all RASSF7 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
H-RAS-03
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Peptide corresponding to amino acids DIHQYREQIKRVKDSDDC of human H-Ras protein
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Purity
>95% by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ras Association Domain Family Member 7
Introduction
RASSF7 was found to be expressed in several embryonic tissues including the skin, eyes, and neural tube.
Entrez Gene ID
UniProt ID
Alternative Names
Ras Association Domain Family Member 7; Ras Association (RalGDS/AF-6) Domain Family (N-Terminal) Member 7; HRAS1-Related Cluster Protein 1; C11orf13; HRC1; Ras Association (RalGDS/AF-6) Domain Family 7
Function
Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization.
Biological Process
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process regulation of microtubule cytoskeleton organizationIEA:InterPro
Biological Process signal transductionIEA:InterPro
Cellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Colocalizes with gamma-tubulin.
PTM
Polyubiquitinated and degraded by the proteasome upon prolonged stress stimuli.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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