RBM10

The protein encoded by this gene contains RNA recognition motif found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. In vitro studies showed that the rat homolog bound to RNA homopolymers, with a preference for G and U polyribonucleotides. This gene is part of a gene cluster on chromosome Xp11.23, and its 3' end lies within 20 kb upstream of UBE1. Two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq]

Full Name

RNA binding motif protein 10

Function

May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity).
May bind to specific miRNA hairpins (PubMed:28431233).

Biological Process

Biological Process 3'-UTR-mediated mRNA stabilizationIEA:Ensembl
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of mRNA splicing, via spliceosomeIEA:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Biological Process negative regulation of vascular associated smooth muscle cell proliferationIEA:Ensembl
Biological Process positive regulation of vascular associated smooth muscle cell apoptotic processIEA:Ensembl
Biological Process regulation of alternative mRNA splicing, via spliceosomeIEA:InterPro
Biological Process vascular associated smooth muscle cell apoptotic processIEA:Ensembl
Biological Process vascular associated smooth muscle cell proliferationIEA:Ensembl

Cellular Location

Nucleus
In the extranucleolar nucleoplasm constitutes hundreds of nuclear domains, which dynamically change their structures in a reversible manner. Upon globally reducing RNA polymerase II transcription, the nuclear bodies enlarge and decrease in number. They occur closely adjacent to nuclear speckles or IGCs (interchromatin granule clusters) but coincide with TIDRs (transcription-inactivation-dependent RNA domains).

Involvement in disease

TARP syndrome (TARPS):
A disorder characterized by the Robin sequence (micrognathia, glossoptosis and cleft palate), talipes equinovarus and cardiac defects.