Sign in or Register   Sign in or Register
  |  

Mouse Anti-RBM10 Recombinant Antibody (2F12) (CBMAB-R1716-CN)

This product is a Mouse antibody that recognizes RBM10. The antibody 2F12 can be used for immunoassay techniques such as: ELISA, WB.
See all RBM10 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2F12
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa. 123-231 from RBM10 (NP_690595) with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
RNA binding motif protein 10
Introduction
This gene encodes a nuclear protein that belongs to a family proteins that contain an RNA-binding motif. The encoded protein associates with hnRNP proteins and may be involved in regulating alternative splicing. Defects in this gene are the cause of the X-linked recessive disorder, TARP syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2011]
Entrez Gene ID
8241
UniProt ID
P98175
Alternative Names
RNA Binding Motif Protein 10; G Patch Domain-Containing Protein 9; RNA-Binding Protein S1-1; DXS8237E; GPATCH9; GPATC9; S1-1;
Function
May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity).
May bind to specific miRNA hairpins (PubMed:28431233).
Biological Process
Biological Process 3'-UTR-mediated mRNA stabilizationIEA:Ensembl
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of mRNA splicing, via spliceosomeIEA:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Biological Process negative regulation of vascular associated smooth muscle cell proliferationIEA:Ensembl
Biological Process positive regulation of vascular associated smooth muscle cell apoptotic processIEA:Ensembl
Biological Process regulation of alternative mRNA splicing, via spliceosomeIEA:InterPro
Biological Process vascular associated smooth muscle cell apoptotic processIEA:Ensembl
Biological Process vascular associated smooth muscle cell proliferationIEA:Ensembl
Cellular Location
Nucleus
In the extranucleolar nucleoplasm constitutes hundreds of nuclear domains, which dynamically change their structures in a reversible manner. Upon globally reducing RNA polymerase II transcription, the nuclear bodies enlarge and decrease in number. They occur closely adjacent to nuclear speckles or IGCs (interchromatin granule clusters) but coincide with TIDRs (transcription-inactivation-dependent RNA domains).
Involvement in disease
TARP syndrome (TARPS):
A disorder characterized by the Robin sequence (micrognathia, glossoptosis and cleft palate), talipes equinovarus and cardiac defects.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-RBM10 Recombinant Antibody (2F12)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare