Mouse Anti-RBM10 Recombinant Antibody (H-4) (CBMAB-R1717-CN)

Name: Mouse Anti-RBM10 Recombinant Antibody (H-4)
SKU: CBMAB-R1717-CN
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

H-4

Application

WB, IP, IF, ELISA

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

More Infomation

Target

Full Name

RNA binding motif protein 10

Introduction

This gene encodes a nuclear protein that belongs to a family proteins that contain an RNA-binding motif. The encoded protein associates with hnRNP proteins and may be involved in regulating alternative splicing. Defects in this gene are the cause of the X-linked recessive disorder, TARP syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2011]

Entrez Gene ID

8241

UniProt ID

P98175

Alternative Names

RNA Binding Motif Protein 10; G Patch Domain-Containing Protein 9; RNA-Binding Protein S1-1; DXS8237E; GPATCH9; GPATC9; S1-1;

Function

May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity).
May bind to specific miRNA hairpins (PubMed:28431233).

Biological Process

Biological Process 3'-UTR-mediated mRNA stabilizationIEA:Ensembl
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of mRNA splicing, via spliceosomeIEA:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Biological Process negative regulation of vascular associated smooth muscle cell proliferationIEA:Ensembl
Biological Process positive regulation of vascular associated smooth muscle cell apoptotic processIEA:Ensembl
Biological Process regulation of alternative mRNA splicing, via spliceosomeIEA:InterPro
Biological Process vascular associated smooth muscle cell apoptotic processIEA:Ensembl
Biological Process vascular associated smooth muscle cell proliferationIEA:Ensembl

Cellular Location

Nucleus
In the extranucleolar nucleoplasm constitutes hundreds of nuclear domains, which dynamically change their structures in a reversible manner. Upon globally reducing RNA polymerase II transcription, the nuclear bodies enlarge and decrease in number. They occur closely adjacent to nuclear speckles or IGCs (interchromatin granule clusters) but coincide with TIDRs (transcription-inactivation-dependent RNA domains).

Involvement in disease

TARP syndrome (TARPS):
A disorder characterized by the Robin sequence (micrognathia, glossoptosis and cleft palate), talipes equinovarus and cardiac defects.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-RBM10 Recombinant Antibody (2F12) (CAT#: CBMAB-R1716-CN)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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