RDH10

This gene encodes a retinol dehydrogenase, which converts all-trans-retinol to all-trans-retinal, with preference for NADP as a cofactor. Studies in mice suggest that this protein is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development. [provided by RefSeq, Dec 2011]

Full Name

Retinol Dehydrogenase 10

Function

Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol.

Biological Process

Biological Process bud elongation involved in lung branchingIEA:Ensembl
Biological Process ear developmentIEA:Ensembl
Biological Process embryonic camera-type eye developmentIEA:Ensembl
Biological Process embryonic forelimb morphogenesisIEA:Ensembl
Biological Process embryonic viscerocranium morphogenesisIEA:Ensembl
Biological Process gonad developmentIEA:Ensembl
Biological Process in utero embryonic developmentIEA:Ensembl
Biological Process metanephros developmentIEA:Ensembl
Biological Process neural crest cell developmentIEA:Ensembl
Biological Process nose developmentIEA:Ensembl
Biological Process positive regulation of retinoic acid biosynthetic processIEA:Ensembl
Biological Process primary lung bud formationIEA:Ensembl
Biological Process retinal metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process retinoic acid biosynthetic processIEA:Ensembl
Biological Process retinoid metabolic processTAS:Reactome
Biological Process retinol metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process visual perceptionManual Assertion Based On ExperimentIDA:MGI

Cellular Location

Microsome membrane
Endoplasmic reticulum membrane

Topology

Helical: 3-23