RNF130

The protein encoded by this gene contains a RING finger motif and is similar to g1, a Drosophila zinc-finger protein that is expressed in mesoderm and involved in embryonic development. The expression of the mouse counterpart was found to be upregulated in myeloblastic cells following IL3 deprivation, suggesting that this gene may regulate growth factor withdrawal-induced apoptosis of myeloid precursor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Full Name

Ring Finger Protein 130

Function

May have a role during the programmed cell death of hematopoietic cells (By similarity).
Acts as an E3 ubiquitin-protein ligase.

Biological Process

Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process programmed cell deathBy SimilarityISS:UniProtKB
Biological Process ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Membrane
Cytoplasm

Topology

Extracellular: 28-194
Helical: 195-217
Cytoplasmic: 218-419

PTM

In vivo measurements suggest this protein is glycosylated (PubMed:19159218).
In contrast, in vitro experiments failed to detect glycosylation (PubMed:16549277).