ROMO1

The protein encoded by this gene is a mitochondrial membrane protein that is responsible for increasing the level of reactive oxygen species (ROS) in cells. The protein also has antimicrobial activity against a variety of bacteria by inducing bacterial membrane breakage. [provided by RefSeq, Nov 2014]

Full Name

Reactive Oxygen Species Modulator 1

Function

Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.

Biological Process

Biological Process antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to reactive oxygen speciesManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cytolysis by host of symbiont cellsManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense response to bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense response to Gram-negative bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process intracellular protein transport1 PublicationIC:ComplexPortal
Biological Process killing of cells of another organismManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of reactive oxygen species metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein import into mitochondrial matrixManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein insertion into mitochondrial inner membraneManual Assertion Based On ExperimentIBA:GO_Central
Biological Process replicative senescenceManual Assertion Based On ExperimentIMP:GO_Central

Cellular Location

Mitochondrion inner membrane

Topology

Helical: 24-44