RPN1

This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. [provided by RefSeq]
Full Name
ribophorin I
Function
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc3Man9GlcNAc2 in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667).
N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Biological Process
Biological Process protein modification processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process protein N-linked glycosylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein N-linked glycosylation via asparagineManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Endoplasmic reticulum
Endoplasmic reticulum membrane
Melanosome
Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Topology
Lumenal: 24-438
Helical: 439-457
Cytoplasmic: 458-607
PTM
Ufmylated by UFL1 in response to endoplasmic reticulum stress, promoting reticulophagy of endoplasmic reticulum sheets.
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Anti-RPN1 antibodies

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Mouse Anti-RPN1 Recombinant Antibody (CBCNR-732) (CBMAB-R3425-CN)

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Target: RPN1
Host: Mouse
Specificity: Human
Clone: CBCNR-732
Application*: WB, ICC, P, C, E
Datasheet SDS

Mouse Anti-RPN1 Recombinant Antibody (CBCNR-731) (CBMAB-R3424-CN)

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Target: RPN1
Host: Mouse
Specificity: Human
Clone: CBCNR-731
Application*: WB
Datasheet SDS

Mouse Anti-RPN1 Recombinant Antibody (CBCNR-729) (CBMAB-R3422-CN)

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Target: RPN1
Host: Mouse
Specificity: Human
Clone: CBCNR-729
Application*: WB
Datasheet SDS

Mouse Anti-RPN1 Recombinant Antibody (CBCNR-495) (CBMAB-R3421-CN)

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Target: RPN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBCNR-495
Application*: WB
Datasheet SDS

Mouse Anti-RPN1 Recombinant Antibody (6F2) (CBMAB-R3418-CN)

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Target: RPN1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 6F2
Application*: WB, IF, F
Datasheet SDS

Mouse Anti-RPN1 Recombinant Antibody (6A9) (CBMAB-R3417-CN)

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Target: RPN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog
Clone: 6A9
Application*: WB, IH, IF, F
Datasheet SDS

Mouse Anti-RPN1 Recombinant Antibody (5B1) (CBMAB-R3416-CN)

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Target: RPN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5B1
Application*: WB, IH, IF, F
Datasheet SDS

Mouse Anti-RPN1 Recombinant Antibody (5A1) (CBMAB-R3415-CN)

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Target: RPN1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5A1
Application*: WB, IF, F
Datasheet SDS

Mouse Anti-RPN1 Recombinant Antibody (3H3) (CBMAB-R3413-CN)

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Target: RPN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Monkey
Clone: 3H3
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-RPN1 Recombinant Antibody (3E1) (CBMAB-R3412-CN)

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Target: RPN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Monkey
Clone: 3E1
Application*: WB, IH, IF, F
Datasheet SDS

Mouse Anti-RPN1 Recombinant Antibody (2G9) (CBMAB-R3411-CN)

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Target: RPN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2G9
Application*: WB, F
Datasheet SDS

Mouse Anti-RPN1 Recombinant Antibody (2G1) (CBMAB-R3410-CN)

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Target: RPN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog
Clone: 2G1
Application*: WB, IF, F
Datasheet SDS

Mouse Anti-RPN1 Recombinant Antibody (2E3) (CBMAB-R3409-CN)

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Target: RPN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog
Clone: 2E3
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-RPN1 Recombinant Antibody (2C10-2F6) (CBMAB-R3408-CN)

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Target: RPN1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2C10-2F6
Application*: E, WB
Datasheet SDS

Mouse Anti-RPN1 Recombinant Antibody (1G5) (CBMAB-R3407-CN)

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Target: RPN1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1G5
Application*: WB, IF, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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