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Mouse Anti-RPN1 Recombinant Antibody (1G5) (CBMAB-R3407-CN)

This product is a Mouse antibody that recognizes RPN1. The antibody 1G5 can be used for immunoassay techniques such as: WB, IF, FC.
See all RPN1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1G5
Antibody Isotype
IgG2a
Application
WB, IF, FC

Basic Information

Immunogen
Full length human recombinant protein of human RPN1 (NP_002941) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium azide
Concentration
1.1 mg/mL

Target

Full Name
ribophorin I
Introduction
This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. [provided by RefSeq, Jul 2008]
Entrez Gene ID
6184
UniProt ID
P04843
Alternative Names
Ribophorin I; Oligosaccharyltransferase Complex Subunit (Non-Catalytic); Ribophorin-1; RPN-I; Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase 67 KDa Subunit; Dolichyl-Diphosphooligosaccharide-Protein Glycosyltransferase 67 KDa Subunit; Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit 1;
Function
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc3Man9GlcNAc2 in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667).
N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Biological Process
Biological Process protein modification processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process protein N-linked glycosylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein N-linked glycosylation via asparagineManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Endoplasmic reticulum
Endoplasmic reticulum membrane
Melanosome
Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Topology
Lumenal: 24-438
Helical: 439-457
Cytoplasmic: 458-607
PTM
Ufmylated by UFL1 in response to endoplasmic reticulum stress, promoting reticulophagy of endoplasmic reticulum sheets.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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