RRP8

RRP8 (Ribosomal RNA Processing 8) is a Protein Coding gene. Diseases associated with RRP8 include Breast Abscess and Bowen-Conradi Syndrome. Among its related pathways are Gene Expression and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include methylated histone binding.

Full Name

ribosomal RNA processing 8

Function

Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.

Biological Process

Biological Process cellular response to glucose starvationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process energy homeostasisManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process intrinsic apoptotic signaling pathway by p53 class mediatorManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process methylationIEA:UniProtKB-KW
Biological Process negative regulation of cell cycleManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process negative regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process positive regulation of histone deacetylationManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process positive regulation of histone methylationManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process rDNA heterochromatin assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of G1 to G0 transitionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of transcription by glucoseManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process rRNA processingIEA:UniProtKB-KW

Cellular Location

Nucleus, nucleolus
Localizes at rDNA locus.