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Rabbit Anti-RRP8 Recombinant Antibody (EG1595) (CBMAB-EN1908-LY)

The product is antibody recognizes HUCE1. The antibody EG1595 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:20000.
See all RRP8 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1595
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:20000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human HUCE1.
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
ribosomal RNA processing 8
Entrez Gene ID
23378
UniProt ID
O43159
Alternative Names
NML; KIAA0409
Function
Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Biological Process
Biological Process cellular response to glucose starvationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process energy homeostasisManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process intrinsic apoptotic signaling pathway by p53 class mediatorManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process methylationIEA:UniProtKB-KW
Biological Process negative regulation of cell cycleManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process negative regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process positive regulation of histone deacetylationManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process positive regulation of histone methylationManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process rDNA heterochromatin assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of G1 to G0 transitionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of transcription by glucoseManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process rRNA processingIEA:UniProtKB-KW
Cellular Location
Nucleus, nucleolus
Localizes at rDNA locus.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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