Rabbit Anti-RRP8 Recombinant Antibody (EG1595) (CBMAB-EN1908-LY)

Name: Rabbit Anti-RRP8 Recombinant Antibody (EG1595)
SKU: CBMAB-EN1908-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

EG1595

Application

WB: 1:500~1:1000 ELISA: 1:20000

Immunogen

The antibody was produced against synthesized peptide derived from internal of human HUCE1.

Specificity

Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

ribosomal RNA processing 8

Entrez Gene ID

23378

UniProt ID

O43159

Alternative Names

NML; KIAA0409

Function

Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.

Biological Process

Biological Process cellular response to glucose starvationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process energy homeostasisManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process intrinsic apoptotic signaling pathway by p53 class mediatorManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process methylationIEA:UniProtKB-KW
Biological Process negative regulation of cell cycleManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process negative regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process positive regulation of histone deacetylationManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process positive regulation of histone methylationManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process rDNA heterochromatin assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of G1 to G0 transitionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of transcription by glucoseManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process rRNA processingIEA:UniProtKB-KW

Cellular Location

Nucleus, nucleolus
Localizes at rDNA locus.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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