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RUVBL1

This gene encodes a protein that has both DNA-dependent ATPase and DNA helicase activities and belongs to the ATPases associated with diverse cellular activities (AAA+) protein family. The encoded protein associates with several multisubunit transcriptional complexes and with protein complexes involved in both ATP-dependent remodeling and histone modification. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Full Name
RUVBL1
Function
Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (PubMed:17157868, PubMed:33205750).
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270).
This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270).
This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed:14966270).
The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed:14966270).
Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (PubMed:24463511).
Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (PubMed:16230350, PubMed:21303910).
Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex (PubMed:10882073, PubMed:16014379).
Essential for cell proliferation (PubMed:14506706).
May be able to bind plasminogen at cell surface and enhance plasminogen activation (PubMed:11027681).
Biological Process
Biological Process box C/D snoRNP assemblyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell cycleIEA:UniProtKB-KW
Biological Process cell divisionIEA:UniProtKB-KW
Biological Process chromatin remodelingManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process DNA recombinationIEA:UniProtKB-KW
Biological Process DNA repairIEA:UniProtKB-KW
Biological Process histone acetylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process histone exchange1 PublicationIC:ComplexPortal
Biological Process histone H2A acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process histone H4 acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process positive regulation of double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process positive regulation of telomerase RNA localization to Cajal bodyManual Assertion Based On ExperimentHMP:BHF-UCL
Biological Process positive regulation of telomere maintenance in response to DNA damageIEA:Ensembl
Biological Process protein stabilization3 PublicationsIC:ComplexPortal
Biological Process regulation of apoptotic process1 PublicationIC:ComplexPortal
Biological Process regulation of cell cycleManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process regulation of chromosome organizationManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process regulation of DNA replicationManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process regulation of DNA strand elongationManual Assertion Based On ExperimentIMP:ComplexPortal
Biological Process regulation of DNA-templated transcription1 PublicationIC:ComplexPortal
Biological Process regulation of double-strand break repair1 PublicationIC:ComplexPortal
Biological Process regulation of embryonic developmentIEA:Ensembl
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process spermatogenesisManual Assertion Based On ExperimentTAS:ProtInc
Biological Process telomere maintenanceIEA:Ensembl
Cellular Location
Nucleus matrix
Nucleus, nucleoplasm
Cytoplasm
Membrane
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Dynein axonemal particle
Mainly localized in the nucleus, associated with nuclear matrix or in the nuclear cytosol, although it is also present in the cytoplasm and associated with the cell membranes. In prophase and prometaphase it is located at the centrosome and the branching microtubule spindles. After mitotic nuclear membrane disintigration it accumulates at the centrosome and sites of tubulin polymerization. As cells pass through metaphase and into telophase it is located close to the centrosome at the early phase of tubulin polymerization. In anaphase it accumulates at the zone of tubule interdigitation. In telophase it is found at polar tubule overlap, and it reappears at the site of chromosomal decondensation in the daughter cells.

Anti-RUVBL1 antibodies

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Target: RUVBL1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1D6
Application*: WB, F, E, IF
Target: RUVBL1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2943C1a
Application*: DB, ICC, WB, F
Target: RUVBL1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3G4-1F8
Application*: WB, E, IF
Target: RUVBL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 507CT2.2.2
Application*: WB
Target: RUVBL1
Host: Mouse
Specificity: Human
Clone: 8C296
Application*: F, ICC, WB
Target: RUVBL1
Host: rabbit
Specificity: Human, Monkey, Mouse, Rat
Clone: D1L8J
Application*: WB, CI
Target: RUVBL1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1A1
Application*: IP, M, WB, CI
Target: RUVBL1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A-11
Application*: WB, IP, IF, E
Target: RUVBL1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A-4
Application*: WB, IP, IF, E
Target: RUVBL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CBYC-P823
Application*: WB, CI
Target: RUVBL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1648
Application*: E, WB
Target: RUVBL1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-1649
Application*: IP, WB
Target: RUVBL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1650
Application*: WB
Target: RUVBL1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-1651
Application*: F, IC, WB
Target: RUVBL1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBYJT-1652
Application*: WB, P, F, IC, IF
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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