S100A14

This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function (PMID: 19956863, 19351828).

Full Name

S100 Calcium Binding Protein A14

Function

Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium.

Biological Process

Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process calcium ion homeostasis1 PublicationNAS:UniProtKB
Biological Process defense response to bacteriumManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process positive regulation of granulocyte chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of monocyte chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to lipopolysaccharideManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process toll-like receptor 4 signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm