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S100A14

This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function (PMID: 19956863, 19351828).

Full Name

S100 Calcium Binding Protein A14

Function

Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium.

Biological Process

Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process calcium ion homeostasis1 PublicationNAS:UniProtKB
Biological Process defense response to bacteriumManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process positive regulation of granulocyte chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of monocyte chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to lipopolysaccharideManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process toll-like receptor 4 signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm

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Anti-S100A14 antibodies

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Mouse Anti-S100A14 Recombinant Antibody (CBXS-0074) (CBMAB-S3074-CQ)

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Target: S100A14

Host: Mouse

Specificity: Human

Clone: CBXS-0074

Application*: WB, IC, P, C, E

Mouse Anti-S100A14 Recombinant Antibody (CBXS-5121) (CBMAB-S2339-CQ)

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Target: S100A14

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-5121

Application*: E, P

Mouse Anti-S100A14 Recombinant Antibody (CBXS-4638) (CBMAB-S1877-CQ)

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Target: S100A14

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-4638

Application*: WB

Human Recombinant S100A14 protein, His Tag (V2LY-0526-LY6644)

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Target: S100A14

Expressed Host: E. coli

Sequence: Amino Acid: 2-104

Tag: His Tag

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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