S1PR2

This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. The encoded protein is a receptor for sphingosine 1-phosphate, which participates in cell proliferation, survival, and transcriptional activation. Defects in this gene have been associated with congenital profound deafness. [provided by RefSeq, Mar 2016]

Full Name

Sphingosine-1-Phosphate Receptor 2

Function

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (PubMed:10617617).
S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues (PubMed:10617617).
When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis (PubMed:10617617).
Receptor for the chemokine-like protein FAM19A5 (PubMed:29453251).
Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity).

Biological Process

Biological Process actin cytoskeleton reorganizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process excitatory postsynaptic potentialIEA:Ensembl
Biological Process filopodium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:MGI
Biological Process negative regulation of excitatory postsynaptic potentialIEA:Ensembl
Biological Process negative regulation of smooth muscle cell migrationIEA:Ensembl
Biological Process negative regulation of vascular associated smooth muscle cell proliferationIEA:Ensembl
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process positive regulation of establishment of endothelial barrierManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of peptidyl-threonine phosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sphingosine-1-phosphate receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cell membrane

Involvement in disease

Deafness, autosomal recessive, 68 (DFNB68):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

Topology

Extracellular: 1-34
Helical: 35-59
Cytoplasmic: 60-66
Helical: 67-95
Extracellular: 96-109
Helical: 110-128
Cytoplasmic: 129-147
Helical: 148-173
Extracellular: 174-189
Helical: 190-210
Cytoplasmic: 211-233
Helical: 234-255
Extracellular: 256-271
Helical: 272-292
Cytoplasmic: 293-353