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Mouse Anti-S1PR2 Recombinant Antibody (CBXS-1798) (CBMAB-S0116-CQ)

This product is a mouse antibody that recognizes S1PR2. The antibody CBXS-1798 can be used for immunoassay techniques such as: FC.
See all S1PR2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-1798
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
NS0 mouse myeloma cell line transfected with human S1P2/EDG-5, Met1-Val353, Accession # AAC98919
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
A saline solution, BSA
Preservative
Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Sphingosine-1-Phosphate Receptor 2
Introduction
This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. The encoded protein is a receptor for sphingosine 1-phosphate, which participates in cell proliferation, survival, and transcriptional activation. Defects in this gene have been associated with congenital profound deafness.
Entrez Gene ID
9294
UniProt ID
O95136
Alternative Names
Sphingosine-1-Phosphate Receptor 2; Endothelial Differentiation, Sphingolipid G-Protein-Coupled Receptor, 5; Endothelial Differentiation G-Protein Coupled Receptor 5; Sphingosine 1-Phosphate Receptor Edg-5; Deafness, Autosomal Recessive 68; S1P Receptor Edg-5; S1P Receptor 2; EDG5; S1P2; Sphingosine 1-Phosphate Receptor 2;
Function
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (PubMed:10617617).
S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues (PubMed:10617617).
When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis (PubMed:10617617).
Receptor for the chemokine-like protein FAM19A5 (PubMed:29453251).
Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity).
Biological Process
Biological Process actin cytoskeleton reorganizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process excitatory postsynaptic potentialIEA:Ensembl
Biological Process filopodium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:MGI
Biological Process negative regulation of excitatory postsynaptic potentialIEA:Ensembl
Biological Process negative regulation of smooth muscle cell migrationIEA:Ensembl
Biological Process negative regulation of vascular associated smooth muscle cell proliferationIEA:Ensembl
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process positive regulation of establishment of endothelial barrierManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of peptidyl-threonine phosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sphingosine-1-phosphate receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell membrane
Involvement in disease
Deafness, autosomal recessive, 68 (DFNB68):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Topology
Extracellular: 1-34
Helical: 35-59
Cytoplasmic: 60-66
Helical: 67-95
Extracellular: 96-109
Helical: 110-128
Cytoplasmic: 129-147
Helical: 148-173
Extracellular: 174-189
Helical: 190-210
Cytoplasmic: 211-233
Helical: 234-255
Extracellular: 256-271
Helical: 272-292
Cytoplasmic: 293-353
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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