SBNO2

SBNO2 (Strawberry Notch Homolog 2) is a Protein Coding gene. An important paralog of this gene is SBNO1.

Full Name

Strawberry Notch Homolog 2

Function

Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation (By similarity).
Involved in the transcriptional corepression of NF-kappaB in macrophages (PubMed:18025162).
Plays a role as a regulator in the pro-inflammatory cascade (PubMed:18025162).

Biological Process

Biological Process bone mineralizationIEA:Ensembl
Biological Process bone trabecula morphogenesisIEA:Ensembl
Biological Process cellular response to interleukin-11ISS:UniProtKB
Biological Process cellular response to interleukin-6Manual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to leukemia inhibitory factorISS:UniProtKB
Biological Process cellular response to lipopolysaccharideISS:UniProtKB
Biological Process macrophage activation involved in immune responseManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process osteoclast differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process osteoclast fusionIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of inflammatory responseManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus