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Mouse Anti-SBNO2 Recombinant Antibody (CBXS-2019) (CBMAB-S4786-CQ)

This product is a mouse antibody that recognizes SBNO2. The antibody CBXS-2019 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all SBNO2 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBXS-2019
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Strawberry Notch Homolog 2
Introduction
SBNO2 (Strawberry Notch Homolog 2) is a Protein Coding gene. An important paralog of this gene is SBNO1.
Entrez Gene ID
Human22904
Mouse216161
Rat314619
UniProt ID
HumanQ9Y2G9
MouseQ7TNB8
RatD3ZDU8
Alternative Names
Strawberry Notch Homolog 2; KIAA0963; Strawberry Notch Homolog 2 (Drosophila); Protein Strawberry Notch Homolog 2; STNO; Sno;
Function
Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation (By similarity).
Involved in the transcriptional corepression of NF-kappaB in macrophages (PubMed:18025162).
Plays a role as a regulator in the pro-inflammatory cascade (PubMed:18025162).
Biological Process
Biological Process bone mineralizationIEA:Ensembl
Biological Process bone trabecula morphogenesisIEA:Ensembl
Biological Process cellular response to interleukin-11ISS:UniProtKB
Biological Process cellular response to interleukin-6Manual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to leukemia inhibitory factorISS:UniProtKB
Biological Process cellular response to lipopolysaccharideISS:UniProtKB
Biological Process macrophage activation involved in immune responseManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process osteoclast differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process osteoclast fusionIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of inflammatory responseManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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