Mouse Anti-SBNO2 Recombinant Antibody (CBXS-2019) (CBMAB-S4786-CQ)

Name: Mouse Anti-SBNO2 Recombinant Antibody (CBXS-2019)
SKU: CBMAB-S4786-CQ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBXS-2019

Application

WB, IP, IF, ELISA

Specificity

Mouse, Rat, Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Strawberry Notch Homolog 2

Introduction

SBNO2 (Strawberry Notch Homolog 2) is a Protein Coding gene. An important paralog of this gene is SBNO1.

Entrez Gene ID

Human	22904
Mouse	216161
Rat	314619

UniProt ID

Human	Q9Y2G9
Mouse	Q7TNB8
Rat	D3ZDU8

Alternative Names

Strawberry Notch Homolog 2; KIAA0963; Strawberry Notch Homolog 2 (Drosophila); Protein Strawberry Notch Homolog 2; STNO; Sno;

Function

Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation (By similarity).
Involved in the transcriptional corepression of NF-kappaB in macrophages (PubMed:18025162).
Plays a role as a regulator in the pro-inflammatory cascade (PubMed:18025162).

Biological Process

Biological Process bone mineralizationIEA:Ensembl
Biological Process bone trabecula morphogenesisIEA:Ensembl
Biological Process cellular response to interleukin-11ISS:UniProtKB
Biological Process cellular response to interleukin-6Manual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to leukemia inhibitory factorISS:UniProtKB
Biological Process cellular response to lipopolysaccharideISS:UniProtKB
Biological Process macrophage activation involved in immune responseManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process osteoclast differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process osteoclast fusionIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of inflammatory responseManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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