SCG5

This gene encodes a secreted chaperone protein that prevents the aggregation of other secreted proteins, including proteins that are associated with neurodegenerative and metabolic disease. The encoded protein may be best known for its role in the trafficking and activation of prohormone convertase PC2 (encoded by Gene ID: 5126). Phosphorylation of the encoded protein has been shown to have an inhibitory effect on its chaperone function.
Full Name
secretogranin V (7B2 protein)
Function
Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
Biological Process
Biological Process intracellular protein transportISS:UniProtKB
Biological Process neuropeptide signaling pathwayIEA:UniProtKB-KW
Biological Process peptide hormone processingISS:UniProtKB
Biological Process regulation of hormone secretionISS:UniProtKB
Cellular Location
Secreted
Neuroendocrine and endocrine secretory granules.
PTM
Proteolytically cleaved in the Golgi by a furin-like convertase to generate bioactive peptides.
Sulfated on tyrosine residues.
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Anti-SCG5 antibodies

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Mouse Anti-SCG5 Recombinant Antibody (8G11) (CBMAB-A7912-LY)

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Target: SCG5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 8G11
Application*: WB, E
Datasheet SDS

Mouse Anti-SCG5 Recombinant Antibody (CBXS-3496) (CBMAB-S6226-CQ)

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Target: SCG5
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXS-3496
Application*: E, WB
Datasheet SDS

Mouse Anti-SCG5 Recombinant Antibody (CBXS-0139) (CBMAB-S3130-CQ)

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Target: SCG5
Host: Mouse
Specificity: Human
Clone: CBXS-0139
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-SCG5 (AA 59-160) Recombinant Antibody (CBXS-0138) (CBMAB-S3129-CQ)

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Target: SCG5
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-0138
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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