Mouse Anti-SCG5 Recombinant Antibody (CBXS-3496) (CBMAB-S6226-CQ)

Name: Mouse Anti-SCG5 Recombinant Antibody (CBXS-3496)
SKU: CBMAB-S6226-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-3496

Application

ELISA, WB

Immunogen

Partial recombinant protein corresponding to aa59-160 of human Secretogranin-5 with a GST tag

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Concentration

LYOPH

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

secretogranin V (7B2 protein)

Introduction

This gene encodes a secreted chaperone protein that prevents the aggregation of other secreted proteins, including proteins that are associated with neurodegenerative and metabolic disease. The encoded protein may be best known for its role in the trafficking and activation of prohormone convertase PC2 (encoded by Gene ID: 5126). Phosphorylation of the encoded protein has been shown to have an inhibitory effect on its chaperone function.

Entrez Gene ID

Human	6447
Mouse	20394
Rat	25719

UniProt ID

Human	P05408
Mouse	P12961
Rat	P27682

Alternative Names

Secretogranin V; Secretory Granule, Neuroendocrine Protein 1 (7B2 Protein); Secretory Granule Endocrine Protein I; Prohormone Convertase Chaperone; Pituitary Polypeptide; Secretogranin-5;

Function

Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.

Biological Process

Biological Process intracellular protein transportISS:UniProtKB
Biological Process neuropeptide signaling pathwayIEA:UniProtKB-KW
Biological Process peptide hormone processingISS:UniProtKB
Biological Process regulation of hormone secretionISS:UniProtKB

Cellular Location

Secreted
Neuroendocrine and endocrine secretory granules.

PTM

Proteolytically cleaved in the Golgi by a furin-like convertase to generate bioactive peptides.
Sulfated on tyrosine residues.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-SCG5 Recombinant Antibody (8G11) (CAT#: CBMAB-A7912-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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