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Mouse Anti-SCG5 Recombinant Antibody (8G11) (CBMAB-A7912-LY)

The product is antibody recognizes SCG5. The antibody 8G11 immunoassay techniques such as: WB, ELISA.
See all SCG5 antibodies
Published Data
Fig. 1 Detection of PC1, PC2 and 7B2 protein by Western blotting of crude cell lysates prepared from normal nasal mucosa.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
8G11
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
SCG5 (NP_003011, 59 a.a. ~ 159 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
secretogranin V (7B2 protein)
Entrez Gene ID
6447
UniProt ID
P05408
Alternative Names
7B2; P7B2; SGNE1; SgV
Function
Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
Biological Process
Biological Process intracellular protein transportISS:UniProtKB
Biological Process neuropeptide signaling pathwayIEA:UniProtKB-KW
Biological Process peptide hormone processingISS:UniProtKB
Biological Process regulation of hormone secretionISS:UniProtKB
Cellular Location
Secreted
Neuroendocrine and endocrine secretory granules.
PTM
Proteolytically cleaved in the Golgi by a furin-like convertase to generate bioactive peptides.
Sulfated on tyrosine residues.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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