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Mouse Anti-SCG5 (AA 59-160) Recombinant Antibody (CBXS-0138) (CBMAB-S3129-CQ)

This product is a mouse antibody that recognizes SCG5. The antibody CBXS-0138 can be used for immunoassay techniques such as: ELISA, WB.
See all SCG5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0138
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 59-160

Target

Full Name
secretogranin V (7B2 protein)
Introduction
This gene encodes a secreted chaperone protein that prevents the aggregation of other secreted proteins, including proteins that are associated with neurodegenerative and metabolic disease. The encoded protein may be best known for its role in the trafficking and activation of prohormone convertase PC2 (encoded by Gene ID: 5126). Phosphorylation of the encoded protein has been shown to have an inhibitory effect on its chaperone function.
Entrez Gene ID
6447
UniProt ID
P05408
Alternative Names
Secretogranin V; Secretory Granule, Neuroendocrine Protein 1 (7B2 Protein); Secretory Granule Endocrine Protein I; Prohormone Convertase Chaperone; Pituitary Polypeptide; Secretogranin-5;
Function
Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
Biological Process
Biological Process intracellular protein transportISS:UniProtKB
Biological Process neuropeptide signaling pathwayIEA:UniProtKB-KW
Biological Process peptide hormone processingISS:UniProtKB
Biological Process regulation of hormone secretionISS:UniProtKB
Cellular Location
Secreted
Neuroendocrine and endocrine secretory granules.
PTM
Proteolytically cleaved in the Golgi by a furin-like convertase to generate bioactive peptides.
Sulfated on tyrosine residues.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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