SENP3

The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]

Full Name

SUMO1/Sentrin/SMT3 Specific Peptidase 3

Function

Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:16608850, PubMed:32832608).
Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability (PubMed:15743823).
Deconjugates SUMO2 and SUMO3 from CDCA8 (PubMed:18946085).
Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 (PubMed:19680224).
Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (PubMed:19015314).
Plays a role in the regulation of sumoylation status of ZNF148 (PubMed:18259216).
Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859).
Deconjugates SUMO2 from KAT5 (PubMed:32832608).

Biological Process

Protein desumoylation

Cellular Location

Nucleus, nucleolus
Nucleus, nucleoplasm
Cytoplasm
Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress (PubMed:19680224).
Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity).