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SERPINF2

This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene.

Full Name

Serpin Family F Member 2

Function

Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin.

Biological Process

Acute-phase response
Blood vessel morphogenesis
Collagen fibril organization
Fibrinolysis
Maintenance of blood vessel diameter homeostasis by renin-angiotensin
Negative regulation of endopeptidase activity
Negative regulation of fibrinolysis
Negative regulation of plasminogen activation
Platelet degranulation
Positive regulation of cell-cell adhesion mediated by cadherin
Positive regulation of cell differentiation
Positive regulation of collagen biosynthetic process
Positive regulation of ERK1 and ERK2 cascade
Positive regulation of JNK cascade
Positive regulation of smooth muscle cell proliferation
Positive regulation of stress fiber assembly
Positive regulation of transcription by RNA polymerase II
Positive regulation of transforming growth factor beta production
Response to organic substance

Cellular Location

Secreted

Involvement in disease

An autosomal recessive disorder resulting in severe hemorrhagic diathesis.

PTM

Proteolytically cleaved at Pro-39 by both the prolyl endopeptidase FAP form and antiplasmin-cleaving enzyme FAP soluble form to generate mature alpha-2-antiplasmin.

Anti-SERPINF2 antibodies

Mouse Anti-SERPINF2 Recombinant Antibody (CBXS-5752) (CBMAB-S0613-CQ)

SDS

Target: SERPINF2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-5752

Application*: E

Rabbit Anti-SERPINF2 Recombinant Antibody (CBXS-3678) (CBMAB-S0955-CQ)

SDS

Target: SERPINF2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBXS-3678

Application*: E, EC

Rat Anti-SERPINF2 Recombinant Antibody (CBXS-4655) (CBMAB-S1894-CQ)

SDS

Target: SERPINF2

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBXS-4655

Application*: WB

Rabbit Anti-SERPINF2 Recombinant Antibody (CBXS-4701) (CBMAB-S1932-CQ)

SDS

Target: SERPINF2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXS-4701

Application*: F

Rat Anti-SERPINF2 Recombinant Antibody (CBXS-1700) (CBMAB-S4538-CQ)

SDS

Target: SERPINF2

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: CBXS-1700

Application*: WB

Mouse Anti-SERPINF2 Recombinant Antibody (CBXS-1715) (CBMAB-S4549-CQ)

SDS

Target: SERPINF2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXS-1715

Application*: WB, IP

Mouse Anti-SERPINF2 Recombinant Antibody (14AP) (CBMAB-A0017-YC)

SDS

Target: SERPINF2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Mammalian

Clone: 14AP

Application*: E

Mouse Anti-SERPINF2 Recombinant Antibody (3AP) (CBMAB-A0019-YC)

SDS

Target: SERPINF2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mammalian

Clone: 3AP

Application*: E

Mouse Anti-SERPINF2 Recombinant Antibody (710-1E-94) (CBMAB-A0020-YC)

SDS

Target: SERPINF2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 710-1E-94

Application*: E, WB

Mouse Anti-SERPINF2 Recombinant Antibody (CBXS-2572) (CBMAB-S5328-CQ)

SDS

Target: SERPINF2

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBXS-2572

Application*: WB

Rat Anti-SERPINF2 Recombinant Antibody (CBXS-2571) (CBMAB-S5327-CQ)

SDS

Target: SERPINF2

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBXS-2571

Application*: WB

Mouse Anti-SERPINF2 Recombinant Antibody (CBYY-I0956) (CBMAB-I2124-YY)

SDS

Target: SERPINF2

Host: Mouse

Antibody Isotype: IgG3, κ

Specificity: Mouse

Clone: CBYY-I0956

Application*: E, WB, I

Mouse Anti-SERPINF2 Recombinant Antibody (CBXS-5609) (CBMAB-S0487-CQ)

SDS

Target: SERPINF2

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBXS-5609

Application*: WB

Mouse Anti-SERPINF2 Recombinant Antibody (CBXS-0259) (CBMAB-S3236-CQ)

SDS

Target: SERPINF2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXS-0259

Application*: E

Mouse Anti-SERPINF2 Recombinant Antibody (CBXS-0261) (CBMAB-S3238-CQ)

SDS

Target: SERPINF2

Host: Mouse

Specificity: Human

Clone: CBXS-0261

Application*: WB, IC, P, C, E

Rabbit Anti-SERPINF2 Recombinant Antibody (CBXS-1048) (CBMAB-S3941-CQ)

SDS

Target: SERPINF2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXS-1048

Application*: WB, E, IP

Rabbit Anti-SERPINF2 Recombinant Antibody (CBXS-1064) (CBMAB-S3955-CQ)

SDS

Target: SERPINF2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXS-1064

Application*: EC

Rabbit Anti-SERPINF2 Recombinant Antibody (CBXS-1105) (CBMAB-S3991-CQ)

SDS

Target: SERPINF2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXS-1105

Application*: ED

Rabbit Anti-SERPINF2 Recombinant Antibody (CBXS-1121) (CBMAB-S4005-CQ)

SDS

Target: SERPINF2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXS-1121

Application*: F

Rabbit Anti-SERPINF2 Recombinant Antibody (CBXS-1130) (CBMAB-S4014-CQ)

SDS

Target: SERPINF2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXS-1130

Application*: E, P

Mouse Anti-SERPINF2 Recombinant Antibody (CBXS-1149) (CBMAB-S4031-CQ)

SDS

Target: SERPINF2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-1149

Application*: F

Mouse Anti-SERPINF2 Recombinant Antibody (14AP) (CBMAB-A4764-YC)

SDS

Target: SERPINF2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 14AP

Application*: FN

Mouse Anti-SERPINF2 Recombinant Antibody (5F78) (CBMAB-A4765-YC)

SDS

Target: SERPINF2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 5F78

Application*: E

Mouse Anti-SERPINF2 Recombinant Antibody (5F85) (CBMAB-A4766-YC)

SDS

Target: SERPINF2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 5F85

Application*: E

Mouse Anti-SERPINF2 Recombinant Antibody (CBYC-A1044) (CBMAB-A4767-YC)

SDS

Target: SERPINF2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYC-A1044

Application*: E, FN

Rabbit Anti-SERPINF2 Recombinant Antibody (CBYC-A1045) (CBMAB-A4768-YC)

SDS

Target: SERPINF2

Host: Rabbit

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: CBYC-A1045

Application*: E, WB

Mouse Anti-SERPINF2 Recombinant Antibody (CBYC-A1046) (CBMAB-A4769-YC)

SDS

Target: SERPINF2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYC-A1046

Application*: E, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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