Human Recombinant SERPINF2 protein, His Tag-1 (V2LY-0526-LY2045)

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Basic Information

Expressed Host
HEK293 Cells
Protein Species
Human
Tag
His Tag
Protein Construction
This product is Human Recombinant SERPINF2 protein, His Tag consist of Amino Acid: 1-491 and predicts a molecular mass of 53.2 kDa.
Molecule Mass
53.2 kDa
Verified
HPLC
Sequence
Amino Acid: 1-491
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
≥97% as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC.
Endotoxin
Please contact us for more information.
Format
Lyophilized
Reconstitution
Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.
Buffer
Lyophilized from sterile Sodium phosphate, NaCl, Imidazole, PMSF, DTT, Glycerol
Preservative
None
Storage
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
More Infomation

Target

Full Name
Serpin Family F Member 2
Function
Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin.
Biological Process
Acute-phase response
Blood vessel morphogenesis
Collagen fibril organization
Fibrinolysis
Maintenance of blood vessel diameter homeostasis by renin-angiotensin
Negative regulation of endopeptidase activity
Negative regulation of fibrinolysis
Negative regulation of plasminogen activation
Platelet degranulation
Positive regulation of cell-cell adhesion mediated by cadherin
Positive regulation of cell differentiation
Positive regulation of collagen biosynthetic process
Positive regulation of ERK1 and ERK2 cascade
Positive regulation of JNK cascade
Positive regulation of smooth muscle cell proliferation
Positive regulation of stress fiber assembly
Positive regulation of transcription by RNA polymerase II
Positive regulation of transforming growth factor beta production
Response to organic substance
Cellular Location
Secreted
Involvement in disease
An autosomal recessive disorder resulting in severe hemorrhagic diathesis.
PTM
Proteolytically cleaved at Pro-39 by both the prolyl endopeptidase FAP form and antiplasmin-cleaving enzyme FAP soluble form to generate mature alpha-2-antiplasmin.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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